Phospholemman (FXYD1)

About Phospholemman

Phospholemman (FXYD1) is a protein from Homo sapiens identified by UniProt accession O00168, 92 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Phospholemman
UniProt accession	O00168
Gene	FXYD1
Organism	Homo sapiens
Length	92 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
hematocrit · score 0.14
hemoglobin measurement · score 0.13
total blood protein measurement · score 0.12
dilated cardiomyopathy 1I · score 0.05
hypertrophic cardiomyopathy · score 0.04
reticulocyte count · score 0.04
arterial calcification, generalized, of infancy, 2 · score 0.03
ATTRV122I amyloidosis · score 0.03
hypertrophic cardiomyopathy 4 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00168-F1	alphafold	PREDICTED	71.47	—

Amino-acid sequence (92 residues)

MASLGHILVF CVGLLTMAKA ESPKEHDPFT YDYQSLQIGG LVIAGILFIL GILIVLSRRC RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards