AH receptor-interacting protein (AIP)

About AH receptor-interacting protein

AH receptor-interacting protein (AIP) is a protein from Homo sapiens identified by UniProt accession O00170, 330 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.

Target properties

Protein name	AH receptor-interacting protein
UniProt accession	O00170
Gene	AIP
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (148)

Diseases linked to this target (Open Targets).

growth hormone-secreting pituitary adenoma · score 0.78
familial isolated pituitary adenoma · score 0.63
acromegaly · score 0.55
hereditary neoplastic syndrome · score 0.55
Inherited cancer-predisposing syndrome · score 0.55
Prolactin-Producing Pituitary Gland Adenoma · score 0.46
malignant endocrine neoplasm · score 0.46
Cushing syndrome · score 0.46
endocrine neoplasm · score 0.46
mean corpuscular hemoglobin · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00170-F1	alphafold	PREDICTED	90.96	—

Amino-acid sequence (330 residues)

MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL DDSRARGKPM ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL VAKSLRNIAV GKDPLEGQRH CCGVAQMREH SSLGHADLDA LQQNPQPLIF HMEMLKVESP GTYQQDPWAM TDEEKAKAVP LIHQEGNRLY REGHVKEAAA KYYDAIACLK NLQMKEQPGS PEWIQLDQQI TPLLLNYCQC KLVVEEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP VVSRELRALE ARIRQKDEED KARFRGIFSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards