Potassium channel subfamily K member 1 (KCNK1)

About Potassium channel subfamily K member 1

Potassium channel subfamily K member 1 (KCNK1) is a protein from Homo sapiens identified by UniProt accession O00180, 336 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Potassium channel subfamily K member 1
UniProt accession	O00180
Gene	KCNK1
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.34
neurofibrillary tangles measurement · score 0.34
lung adenocarcinoma · score 0.23
breast adenocarcinoma · score 0.22
neurodegenerative disease · score 0.20
thyroid gland adenocarcinoma · score 0.18
cutaneous melanoma · score 0.16
drug use measurement · score 0.10
glioblastoma multiforme · score 0.10
breast cancer · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00180-F1	alphafold	PREDICTED	82.92	—

Amino-acid sequence (336 residues)

MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED LLRQELRKLK RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW NWDFTSALFF ASTVLSTTGY GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT AVVQRITVHV TRRPVLYFHI RWGFSKQVVA IVHAVLLGFV TVSCFFFIPA AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK FRELYKIGIT CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards