About Mannan-binding lectin serine protease 2
Mannan-binding lectin serine protease 2 (MASP2) is a protein
from Homo sapiens identified by UniProt accession
O00187, 686 residues long.
MolForge cross-references it against 0 known binders and
227 disease associations.
Target properties
| Protein name | Mannan-binding lectin serine protease 2 |
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| UniProt accession | O00187 |
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| Gene | MASP2 |
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| Organism | Homo sapiens |
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| Length | 686 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (227)
Diseases linked to this target (Open Targets).
- immunodeficiency due to MASP-2 deficiency · score 0.66
- frontotemporal dementia with motor neuron disease · score 0.56
- familial amyotrophic lateral sclerosis · score 0.56
- amyotrophic lateral sclerosis · score 0.56
- GRN-related frontotemporal lobar degeneration with Tdp43 inclusions · score 0.54
- motor neuron disease · score 0.44
- COVID-19 · score 0.39
- frontotemporal dementia · score 0.32
- neurodegenerative disease · score 0.29
- IGA glomerulonephritis · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00187-F1 | alphafold | PREDICTED | 89.44 | — |
Amino-acid sequence (686 residues)
MRLLTLLGLL CGSVATPLGP KWPEPVFGRL ASPGFPGEYA NDQERRWTLT APPGYRLRLY FTHFDLELSH LCEYDFVKLS SGAKVLATLC GQESTDTERA PGKDTFYSLG SSLDITFRSD YSNEKPFTGF EAFYAAEDID ECQVAPGEAP TCDHHCHNHL GGFYCSCRAG YVLHRNKRTC SALCSGQVFT QRSGELSSPE YPRPYPKLSS CTYSISLEEG FSVILDFVES FDVETHPETL CPYDFLKIQT DREEHGPFCG KTLPHRIETK SNTVTITFVT DESGDHTGWK IHYTSTAQPC PYPMAPPNGH VSPVQAKYIL KDSFSIFCET GYELLQGHLP LKSFTAVCQK DGSWDRPMPA CSIVDCGPPD DLPSGRVEYI TGPGVTTYKA VIQYSCEETF YTMKVNDGKY VCEADGFWTS SKGEKSLPVC EPVCGLSART TGGRIYGGQK AKPGDFPWQV LILGGTTAAG ALLYDNWVLT AAHAVYEQKH DASALDIRMG TLKRLSPHYT QAWSEAVFIH EGYTHDAGFD NDIALIKLNN KVVINSNITP ICLPRKEAES FMRTDDIGTA SGWGLTQRGF LARNLMYVDI PIVDHQKCTA AYEKPPYPRG SVTANMLCAG LESGGKDSCR GDSGGALVFL DSETERWFVG GIVSWGSMNC GEAGQYGVYT KVINYIPWIE NIISDF
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