AP-4 complex subunit mu-1 (AP4M1)

About AP-4 complex subunit mu-1

AP-4 complex subunit mu-1 (AP4M1) is a protein from Homo sapiens identified by UniProt accession O00189, 453 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	AP-4 complex subunit mu-1
UniProt accession	O00189
Gene	AP4M1
Organism	Homo sapiens
Length	453 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

Severe intellectual disability and progressive spastic paraplegia · score 0.75
Spastic paraplegia · score 0.71
Intellectual disability · score 0.49
neurodegenerative disease · score 0.48
AP-4 deficiency syndrome · score 0.44
hereditary spastic paraplegia · score 0.41
genetic disorder · score 0.41
Abnormality of the nervous system · score 0.34
Microcephaly · score 0.26
Global developmental delay · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00189-F1	alphafold	PREDICTED	85.44	—

Amino-acid sequence (453 residues)

MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HHGRHFIHIR HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG TISRNVALVY ELLDEVLDYG YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE LRGYGPGIRV DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP SVQWDRGSGR LQVYLKLRCD LLSKSQALNV RLHLPLPRGV VSLSQELSSP EQKAELAEGA LRWDLPRVQG GSQLSGLFQM DVPGPPGPPS HGLSTSASPL GLGPASLSFE LPRHTCSGLQ VRFLRLAFRP CGNANPHKWV RHLSHSDAYV IRI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards