About Ras-related protein Rab-27B
Ras-related protein Rab-27B (RAB27B) is a protein
from Homo sapiens identified by UniProt accession
O00194, 218 residues long.
MolForge cross-references it against 0 known binders and
195 disease associations.
Target properties
| Protein name | Ras-related protein Rab-27B |
|---|
| UniProt accession | O00194 |
|---|
| Gene | RAB27B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 218 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (195)
Diseases linked to this target (Open Targets).
- body mass index · score 0.45
- unipolar depression · score 0.41
- lean body mass · score 0.40
- body weight · score 0.39
- wellbeing measurement · score 0.39
- depressive symptom measurement · score 0.36
- neuroticism measurement · score 0.34
- fat body mass · score 0.32
- base metabolic rate measurement · score 0.29
- hip circumference · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00194-F1 | alphafold | PREDICTED | 84.55 | — |
Amino-acid sequence (218 residues)
MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR VVYNAQGPNG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLPDQ REVNERQARE LADKYGIPYF ETSAATGQNV EKAVETLLDL IMKRMEQCVE KTQIPDTVNG GNSGNLDGEK PPEKKCIC
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