Activator of apoptosis harakiri (HRK)

About Activator of apoptosis harakiri

Activator of apoptosis harakiri (HRK) is a protein from Homo sapiens identified by UniProt accession O00198, 91 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Activator of apoptosis harakiri
UniProt accession	O00198
Gene	HRK
Organism	Homo sapiens
Length	91 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
brain volume measurement · score 0.44
hippocampal volume · score 0.44
neuroimaging measurement · score 0.41
brain measurement · score 0.36
eosinophil count · score 0.35
hippocampal CA4 volume · score 0.29
hippocampus molecular layer volume · score 0.29
granule cell layer dentate gyrus volume · score 0.29
hippocampal CA1 volume · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00198-F1	alphafold	PREDICTED	72.13	—

Amino-acid sequence (91 residues)

MCPCPLHRGR GPPAVCACSA GRLGLRSSAA QLTAARLKAL GDELHQRTMW RRRARSRRAP APGALPTYWP WLCAAAQVAA LAAWLLGRRN L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards