About Hyaluronan synthase 3
Hyaluronan synthase 3 (HAS3) is a protein
from Homo sapiens identified by UniProt accession
O00219, 553 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Hyaluronan synthase 3 |
|---|
| UniProt accession | O00219 |
|---|
| Gene | HAS3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 553 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (134)
Diseases linked to this target (Open Targets).
- non-melanoma skin carcinoma · score 0.13
- skin cancer · score 0.13
- brain measurement · score 0.11
- body height · score 0.11
- cutaneous melanoma · score 0.10
- neoplasm · score 0.09
- renal cell carcinoma · score 0.08
- cortical surface area measurement · score 0.08
- health study participation · score 0.07
- IGF-1 measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00219-F1 | alphafold | PREDICTED | 90.94 | — |
Amino-acid sequence (553 residues)
MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG KKPEQYSLAF AEV
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