NF-kappa-B inhibitor epsilon (NFKBIE)

About NF-kappa-B inhibitor epsilon

NF-kappa-B inhibitor epsilon (NFKBIE) is a protein from Homo sapiens identified by UniProt accession O00221, 500 residues long. MolForge cross-references it against 0 known binders and 204 disease associations.

Target properties

Protein name	NF-kappa-B inhibitor epsilon
UniProt accession	O00221
Gene	NFKBIE
Organism	Homo sapiens
Length	500 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (204)

Diseases linked to this target (Open Targets).

chronic lymphocytic leukemia · score 0.50
diffuse large B-cell lymphoma · score 0.44
melanoma · score 0.40
nodular melanoma · score 0.37
skin basal cell carcinoma · score 0.37
cutaneous melanoma · score 0.37
desmoplastic melanoma · score 0.37
lymphoma · score 0.35
rheumatoid arthritis · score 0.35
lymphoid leukemia · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00221-F1	alphafold	PREDICTED	61.64	—

Amino-acid sequence (500 residues)

MNQRRSESRP GNHRLQAYAE PGKGDSGGAG PLSGSARRGR GGGGAIRVRR PCWSGGAGRG GGPAWAVRLP TVTAGWTWPA LRTLSSLRAG PSEPHSPGRR PPRAGRPLCQ ADPQPGKAAR RSLEPDPAQT GPRPARAAGM SEARKGPDEA EESQYDSGIE SLRSLRSLPE STSAPASGPS DGSPQPCTHP PGPVKEPQEK EDADGERADS TYGSSSLTYT LSLLGGPEAE DPAPRLPLPH VGALSPQQLE ALTYISEDGD TLVHLAVIHE APAVLLCCLA LLPQEVLDIQ NNLYQTALHL AVHLDQPGAV RALVLKGASR ALQDRHGDTA LHVACQRQHL ACARCLLEGR PEPGRGTSHS LDLQLQNWQG LACLHIATLQ KNQPLMELLL RNGADIDVQE GTSGKTALHL AVETQERGLV QFLLQAGAQV DARMLNGCTP LHLAAGRGLM GISSTLCKAG ADSLLRNVED ETPQDLTEES LVLLPFDDLK ISGKLLLCTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards