Cortistatin (CORT)

About Cortistatin

Cortistatin (CORT) is a protein from Homo sapiens identified by UniProt accession O00230, 105 residues long. MolForge cross-references it against 0 known binders and 218 disease associations.

Target properties

Protein name	Cortistatin
UniProt accession	O00230
Gene	CORT
Organism	Homo sapiens
Length	105 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (218)

Diseases linked to this target (Open Targets).

hyperinsulinism due to INSR deficiency · score 0.06
neoplasm · score 0.06
hematocrit · score 0.05
urate measurement · score 0.05
primary ovarian insufficiency · score 0.05
46,XX gonadal dysgenesis · score 0.05
C-reactive protein measurement · score 0.05
MODY · score 0.05
Non-acquired isolated growth hormone deficiency · score 0.05
hemoglobin measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00230-F1	alphafold	PREDICTED	62.83	—

Amino-acid sequence (105 residues)

MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL AWWFEWTSQA SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT FSSCK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards