26S proteasome non-ATPase regulatory subunit 11…

About 26S proteasome non-ATPase regulatory subunit 11

26S proteasome non-ATPase regulatory subunit 11 (PSMD11) is a protein from Homo sapiens identified by UniProt accession O00231, 422 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	26S proteasome non-ATPase regulatory subunit 11
UniProt accession	O00231
Gene	PSMD11
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
neurodegenerative disease · score 0.39
Short stature · score 0.33
breast adenocarcinoma · score 0.30
lung adenocarcinoma · score 0.29
endometrial cancer · score 0.29
esophageal cancer · score 0.28
urinary bladder cancer · score 0.28
head and neck squamous cell carcinoma · score 0.28
squamous cell lung carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00231-F1	alphafold	PREDICTED	82.66	—

Amino-acid sequence (422 residues)

MAAAAVVEFQ RAQSLLSTDR EASIDILHSI VKRDIQENDE EAVQVKEQSI LELGSLLAKT GQAAELGGLL KYVRPFLNSI SKAKAARLVR SLLDLFLDME AATGQEVELC LECIEWAKSE KRTFLRQALE ARLVSLYFDT KRYQEALHLG SQLLRELKKM DDKALLVEVQ LLESKTYHAL SNLPKARAAL TSARTTANAI YCPPKLQATL DMQSGIIHAA EEKDWKTAYS YFYEAFEGYD SIDSPKAITS LKYMLLCKIM LNTPEDVQAL VSGKLALRYA GRQTEALKCV AQASKNRSLA DFEKALTDYR AELRDDPIIS THLAKLYDNL LEQNLIRVIE PFSRVQIEHI SSLIKLSKAD VERKLSQMIL DKKFHGILDQ GEGVLIIFDE PPVDKTYEAA LETIQNMSKV VDSLYNKAKK LT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

26S proteasome non-ATPase regulatory subunit 11 (PSMD11)