About 26S proteasome non-ATPase regulatory subunit 12
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) is a protein
from Homo sapiens identified by UniProt accession
O00232, 456 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | 26S proteasome non-ATPase regulatory subunit 12 |
|---|
| UniProt accession | O00232 |
|---|
| Gene | PSMD12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 456 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- Stankiewicz-Isidor syndrome · score 0.71
- HIV infection · score 0.46
- genetic disorder · score 0.40
- neurodegenerative disease · score 0.39
- complex neurodevelopmental disorder · score 0.37
- breast adenocarcinoma · score 0.30
- endometrial cancer · score 0.29
- lung adenocarcinoma · score 0.28
- urinary bladder cancer · score 0.28
- squamous cell lung carcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00232-F1 | alphafold | PREDICTED | 78.92 | — |
Amino-acid sequence (456 residues)
MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL EKQTRTASDM VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI KLRLIDTLRM VTEGKIYVEI ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK ERVEFILEQM RLCLAVKDYI RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY LSICKHYRAI YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR WKDLKNRVVE HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK TIFAKVDRLA GIINFQRPKD PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE MIHNLQ
Explore 26S proteasome non-ATPase regulatory subunit 12 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets