About E3 ubiquitin-protein ligase RNF103
E3 ubiquitin-protein ligase RNF103 (RNF103) is a protein
from Homo sapiens identified by UniProt accession
O00237, 685 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF103 |
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| UniProt accession | O00237 |
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| Gene | RNF103 |
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| Organism | Homo sapiens |
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| Length | 685 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- body mass index · score 0.23
- body height · score 0.22
- risky sexual behaviour measurement · score 0.13
- low density lipoprotein cholesterol measurement · score 0.12
- blood protein measurement · score 0.09
- anxiety · score 0.05
- unipolar depression · score 0.05
- neuroticism measurement · score 0.05
- hip circumference · score 0.04
- reticulocyte count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00237-F1 | alphafold | PREDICTED | 73.19 | — |
Amino-acid sequence (685 residues)
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL VQVIANDRSP LVGKIHWEKM VKKVSRFGIR TGTFNCSSDP RYCRRRGWVR STLIMSVPQT STSKGKVMLK EYSGRKIEVE HIFKWITAHA ASRIKTIYNA EHLKEEWNKS DQYWLKIYLF ANLDQPPAFF SALSIKFTGR VEFIFVNVEN WDNKSYMTDI GIYNMPSYIL RTPEGIYRYG NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI KRFVVLISTL GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LKLLRYSNTT TLASWVRADW MFYSSHPALF LSTYLGHGLL IDYFEKKRRR NNNNDEVNAN NLEWLSSLWD WYTSYLFHPI ASFQNFPVES DWDEDPDLFL ERLAFPDLWL HPLIPTDYIK NLPMWRFKCL GVQSEEEMSE GSQDTENDSE SENTDTLSSE KEVFEDKQSV LHNSPGTASH CDAEACSCAN KYCQTSPCER KGRSYGSYNT NEDMEPDWLT WPADMLHCTE CVVCLENFEN GCLLMGLPCG HVFHQNCIVM WLAGGRHCCP VCRWPSYKKK QPYAQHQPLS NDVPS
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