About Bone morphogenetic protein receptor type-1B
Bone morphogenetic protein receptor type-1B (BMPR1B) is a protein
from Homo sapiens identified by UniProt accession
O00238, 502 residues long.
MolForge cross-references it against 0 known binders and
454 disease associations.
Target properties
| Protein name | Bone morphogenetic protein receptor type-1B |
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| UniProt accession | O00238 |
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| Gene | BMPR1B |
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| Organism | Homo sapiens |
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| Length | 502 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (454)
Diseases linked to this target (Open Targets).
- brachydactyly type A2 · score 0.76
- acromesomelic dysplasia 3 · score 0.74
- brachydactyly type A1 · score 0.56
- tibia fracture · score 0.50
- bone disease · score 0.46
- acromesomelic dysplasia 2B · score 0.46
- systolic blood pressure · score 0.40
- body mass index · score 0.40
- hemoglobin measurement · score 0.38
- hematocrit · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00238-F1 | alphafold | PREDICTED | 85.10 | — |
Amino-acid sequence (502 residues)
MLLRSAGKLN VGTKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHRALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT LAKMSESQDI KL
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