Signal-regulatory protein beta-1 (SIRPB1)

About Signal-regulatory protein beta-1

Signal-regulatory protein beta-1 (SIRPB1) is a protein from Homo sapiens identified by UniProt accession O00241, 398 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Signal-regulatory protein beta-1
UniProt accession	O00241
Gene	SIRPB1
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.43
monocyte count · score 0.43
leukocyte count · score 0.40
mean platelet volume · score 0.39
neutrophil count · score 0.37
platelet crit · score 0.33
platelet component distribution width · score 0.30
mitochondrial DNA measurement · score 0.29
eosinophil count · score 0.28
lymphocyte percentage of leukocytes · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00241-F1	alphafold	PREDICTED	84.53	—

Amino-acid sequence (398 residues)

MPVPASWPHL PSPFLLMTLL LGRLTGVAGE DELQVIQPEK SVSVAAGESA TLRCAMTSLI PVGPIMWFRG AGAGRELIYN QKEGHFPRVT TVSELTKRNN LDFSISISNI TPADAGTYYC VKFRKGSPDD VEFKSGAGTE LSVRAKPSAP VVSGPAVRAT PEHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPA GDSVSYSIHS TARVVLTRGD VHSQVICEIA HITLQGDPLR GTANLSEAIR VPPTLEVTQQ PMRAENQANV TCQVSNFYPR GLQLTWLENG NVSRTETAST LIENKDGTYN WMSWLLVNTC AHRDDVVLTC QVEHDGQQAV SKSYALEISA HQKEHGSDIT HEAALAPTAP LLVALLLGPK LLLVVGVSAI YICWKQKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards