Agouti-related protein (AGRP)

About Agouti-related protein

Agouti-related protein (AGRP) is a protein from Homo sapiens identified by UniProt accession O00253, 132 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.

Target properties

Protein name	Agouti-related protein
UniProt accession	O00253
Gene	AGRP
Organism	Homo sapiens
Length	132 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (160)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.41
mean corpuscular hemoglobin · score 0.26
BMI-adjusted waist-hip ratio · score 0.24
hematological measurement · score 0.19
BMI-adjusted waist circumference · score 0.19
smoking behavior · score 0.17
mean corpuscular hemoglobin concentration · score 0.17
erythrocyte count · score 0.16
waist-hip ratio · score 0.16
mean reticulocyte volume · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00253-F1	alphafold	PREDICTED	69.53	—

Amino-acid sequence (132 residues)

MLTAAVLSCA LLLALPATRG AQMGLAPMEG IRRPDQALLP ELPGLGLRAP LKKTTAEQAE EDLLQEAQAL AEVLDLQDRE PRSSRRCVRL HESCLGQQVP CCDPCATCYC RFFNAFCYCR KLGTAMNPCS RT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards