About Menin
Menin (MEN1) is a protein
from Homo sapiens identified by UniProt accession
O00255, 610 residues long.
MolForge cross-references it against 0 known binders and
708 disease associations.
Target properties
| Protein name | Menin |
|---|
| UniProt accession | O00255 |
|---|
| Gene | MEN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 610 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (708)
Diseases linked to this target (Open Targets).
- multiple endocrine neoplasia type 1 · score 0.87
- hyperparathyroidism · score 0.69
- parathyroid adenoma · score 0.67
- endocrine neoplasm · score 0.65
- Angiofibroma · score 0.64
- lung carcinoid tumor · score 0.62
- multiple endocrine neoplasia · score 0.61
- hereditary neoplastic syndrome · score 0.56
- Inherited cancer-predisposing syndrome · score 0.56
- pancreatic neuroendocrine tumor · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00255-F1 | alphafold | PREDICTED | 84.42 | — |
Amino-acid sequence (610 residues)
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED HAWVVFGPNG EQTAEVTWHG KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV CAINPSIDLH TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT LYHKGIASAK TYYRDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQSQGTQSQ GSALQDPECF AHLLRFYDGI CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVRIVSR EAEAAEAEEP WGEEAREGRR RGPRRESKPE EPPPPKKPAL DKGLGTGQGA VSGPPRKPPG TVAGTARGPE GGSTAQVPAP TASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL SFLKRQRKGL
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