E3 SUMO-protein ligase CBX4 (CBX4)

About E3 SUMO-protein ligase CBX4

E3 SUMO-protein ligase CBX4 (CBX4) is a protein from Homo sapiens identified by UniProt accession O00257, 560 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	E3 SUMO-protein ligase CBX4
UniProt accession	O00257
Gene	CBX4
Organism	Homo sapiens
Length	560 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.38
body mass index · score 0.30
breast adenocarcinoma · score 0.26
ovarian cancer · score 0.26
endometrial cancer · score 0.25
age at menarche · score 0.21
lung adenocarcinoma · score 0.21
esophageal cancer · score 0.20
head and neck squamous cell carcinoma · score 0.18
total blood protein measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00257-F1	alphafold	PREDICTED	54.04	—

Amino-acid sequence (560 residues)

MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR ERQEQLMGYR KRGPKPKPLV VQVPTFARRS NVLTGLQDSS TDNRAKLDLG AQGKGQGHQY ELNSKKHHQY QPHSKERAGK PPPPGKSGKY YYQLNSKKHH PYQPDPKMYD LQYQGGHKEA PSPTCPDLGA KSHPPDKWAQ GAGAKGYLGA VKPLAGAAGA PGKGSEKGPP NGMMPAPKEA VTGNGIGGKM KIVKNKNKNG RIVIVMSKYM ENGMQAVKIK SGEVAEGEAR SPSHKKRAAD ERHPPADRTF KKAAGAEEKK VEAPPKRREE EVSGVSDPQP QDAGSRKLSP TKEAFGEQPL QLTTKPDLLA WDPARNTHPP SHHPHPHPHH HHHHHHHHHH AVGLNLSHVR KRCLSETHGE REPCKKRLTA RSISTPTCLG GSPAAERPAD LPPAAALPQP EVILLDSDLD EPIDLRCVKT RSEAGEPPSS LQVKPETPAS AAVAVAAAAA PTTTAEKPPA EAQDEPAESL SEFKPFFGNI IITDVTANCL TVTFKEYVTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards