Guided entry of tail-anchored proteins factor 1 (GET1)

About Guided entry of tail-anchored proteins factor 1

Guided entry of tail-anchored proteins factor 1 (GET1) is a protein from Homo sapiens identified by UniProt accession O00258, 174 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Guided entry of tail-anchored proteins factor 1
UniProt accession	O00258
Gene	GET1
Organism	Homo sapiens
Length	174 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

platelet count · score 0.21
mean platelet volume · score 0.21
Esotropia · score 0.11
Non-accomodative esotropia · score 0.11
platelet crit · score 0.10
sitting height measurement · score 0.06
FEV/FVC ratio · score 0.06
inflammatory bowel disease · score 0.05
total cholesterol measurement · score 0.02
body height · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00258-F1	alphafold	PREDICTED	77.69	—

Amino-acid sequence (174 residues)

MSSAAADHWA WLLVLSFVFG CNVLRILLPS FSSFMSRVLQ KDAEQESQMR AEIQDMKQEL STVNMMDEFA RYARLERKIN KMTDKLKTHV KARTAQLAKI KWVISVAFYV LQAALMISLI WKYYSVPVAV VPSKWITPLD RLVAFPTRVA GGVGITCWIL VCNKVVAIVL HPFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards