Membrane-associated progesterone receptor component…

About Membrane-associated progesterone receptor component 1

Membrane-associated progesterone receptor component 1 (PGRMC1) is a protein from Homo sapiens identified by UniProt accession O00264, 195 residues long. MolForge cross-references it against 0 known binders and 190 disease associations.

Target properties

Protein name	Membrane-associated progesterone receptor component 1
UniProt accession	O00264
Gene	PGRMC1
Organism	Homo sapiens
Length	195 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (190)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
total early-onset cataract · score 0.37
genetic non-acquired premature ovarian failure · score 0.35
Cataract · score 0.19
Premature ovarian insufficiency · score 0.18
cataract · score 0.18
hepatocellular carcinoma · score 0.11
neoplasm · score 0.09
breast cancer · score 0.09
cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00264-F1	alphafold	PREDICTED	83.81	—

Amino-acid sequence (195 residues)

MAAEDVVATG ADPSDLESGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ PAASGDSDDD EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTAAQQ ETLSDWESQF TFKYHHVGKL LKEGEEPTVY SDEEEPKDES ARKND

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Membrane-associated progesterone receptor component 1 (PGRMC1)