DNA fragmentation factor subunit alpha (DFFA)

About DNA fragmentation factor subunit alpha

DNA fragmentation factor subunit alpha (DFFA) is a protein from Homo sapiens identified by UniProt accession O00273, 331 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	DNA fragmentation factor subunit alpha
UniProt accession	O00273
Gene	DFFA
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
breast adenocarcinoma · score 0.24
gastric adenocarcinoma · score 0.11
asthma · score 0.11
breast carcinoma · score 0.10
C-reactive protein measurement · score 0.10
prostate carcinoma · score 0.09
estrogen-receptor negative breast cancer · score 0.09
low density lipoprotein cholesterol measurement · score 0.08
total cholesterol measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00273-F1	alphafold	PREDICTED	71.59	—

Amino-acid sequence (331 residues)

MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL AIDKSLTPVT LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD GGTAWISQES FDVDETDSGA GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV DAPCSDLAQE LRQSCATVQR LQHTLQQVLD QREEVRQSKQ LLQLYLQALE KEGSLLSKQE ESKAAFGEEV DAVDTGISRE TSSDVALASH ILTALREKQA PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE RELALRLQQT QSLHSLRSIS ASKASPPGDL QNPKRARQDP T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards