Regulatory factor X-associated protein (RFXAP)

About Regulatory factor X-associated protein

Regulatory factor X-associated protein (RFXAP) is a protein from Homo sapiens identified by UniProt accession O00287, 272 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Regulatory factor X-associated protein
UniProt accession	O00287
Gene	RFXAP
Organism	Homo sapiens
Length	272 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

Immunodeficiency by defective expression of HLA class 2 · score 0.74
MHC class II deficiency · score 0.64
neurodegenerative disease · score 0.27
Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
Fuchs endothelial corneal dystrophy · score 0.05
X-linked endothelial corneal dystrophy · score 0.05
granular corneal dystrophy type I · score 0.05
Thiel-Behnke corneal dystrophy · score 0.04
autosomal dominant keratitis · score 0.04
macular corneal dystrophy · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00287-F1	alphafold	PREDICTED	63.98	—

Amino-acid sequence (272 residues)

MEAQGVAEGA GPGAASGVPH PAALAPAAAP TLAPASVAAA ASQFTLLVMQ PCAGQDEAAA PGGSVGAGKP VRYLCEGAGD GEEEAGEDEA DLLDTSDPPG GGESAASLED LEDEETHSGG EGSSGGARRR GSGGGSMSKT CTYEGCSETT SQVAKQRKPW MCKKHRNKMY KDKYKKKKSD QALNCGGTAS TGSAGNVKLE ESADNILSIV KQRTGSFGDR PARPTLLEQV LNQKRLSLLR SPEVVQFLQK QQQLLNQQVL EQRQQQFPGT SM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards