Left-right determination factor 2 (LEFTY2)

About Left-right determination factor 2

Left-right determination factor 2 (LEFTY2) is a protein from Homo sapiens identified by UniProt accession O00292, 366 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Left-right determination factor 2
UniProt accession	O00292
Gene	LEFTY2
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

left-right axis malformations · score 0.42
Heterotaxia · score 0.23
visceral heterotaxy · score 0.23
protein measurement · score 0.23
glioblastoma multiforme · score 0.14
mean platelet volume · score 0.09
heterotaxy, visceral, 12, autosomal · score 0.07
scimitar syndrome · score 0.06
congenital heart disease · score 0.06
right atrial isomerism · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00292-F1	alphafold	PREDICTED	79.01	—

Amino-acid sequence (366 residues)

MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK LVIPAHVRAQ YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEASTHLLV FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS AQARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLRDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAKN WVLEPPGFLA YECVGTCQQP PEALAFNWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV PRRLQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards