Tubby-related protein 1 (TULP1)

About Tubby-related protein 1

Tubby-related protein 1 (TULP1) is a protein from Homo sapiens identified by UniProt accession O00294, 542 residues long. MolForge cross-references it against 0 known binders and 241 disease associations.

Target properties

Protein name	Tubby-related protein 1
UniProt accession	O00294
Gene	TULP1
Organism	Homo sapiens
Length	542 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (241)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.73
Leber congenital amaurosis · score 0.71
Retinal dystrophy · score 0.53
Leber congenital amaurosis 1 · score 0.50
autosomal recessive retinitis pigmentosa · score 0.46
Posterior column ataxia - retinitis pigmentosa · score 0.40
Stargardt disease · score 0.36
retinal degeneration · score 0.35
Abnormality of the eye · score 0.34
Pigmentary retinopathy · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00294-F1	alphafold	PREDICTED	65.39	—

Amino-acid sequence (542 residues)

MPLRDETLRE VWASDSGHEE ESLSPEAPRR PKQRPAPAQR LRKKRTEAPE SPCPTGSKPR KPGAGRTGRP REEPSPDPAQ ARAPQTVYAR FLRDPEAKKR DPRETFLVAR APDAEDEEEE EEEDEEDEEE EAEEKKEKIL LPPKKPLREK SSADLKERRA KAQGPRGDLG SPDPPPKPLR VRNKEAPAGE GTKMRKTKKK GSGEADKDPS GSPASARKSP AAMFLVGEGS PDKKALKKKG TPKGARKEEE EEEEAATVIK KSNQKGKAKG KGKKKAKEER APSPPVEVDE PREFVLRPAP QGRTVRCRLT RDKKGMDRGM YPSYFLHLDT EKKVFLLAGR KRKRSKTANY LISIDPTNLS RGGENFIGKL RSNLLGNRFT VFDNGQNPQR GYSTNVASLR QELAAVIYET NVLGFRGPRR MTVIIPGMSA ENERVPIRPR NASDGLLVRW QNKTLESLIE LHNKPPVWND DSGSYTLNFQ GRVTQASVKN FQIVHADDPD YIVLQFGRVA EDAFTLDYRY PLCALQAFAI ALSSFDGKLA CE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards