Tubby-related protein 2 (TULP2)

About Tubby-related protein 2

Tubby-related protein 2 (TULP2) is a protein from Homo sapiens identified by UniProt accession O00295, 520 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.

Target properties

Protein name	Tubby-related protein 2
UniProt accession	O00295
Gene	TULP2
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (152)

Diseases linked to this target (Open Targets).

grip strength measurement · score 0.14
COVID-19 · score 0.13
reticulocyte count · score 0.13
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
spermatogenic failure 65 · score 0.08
spermatogenic failure 56 · score 0.08
spermatogenic failure, X-linked, 3 · score 0.07
spermatogenic failure 40 · score 0.07
spermatogenic failure 47 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00295-F1	alphafold	PREDICTED	66.27	—

Amino-acid sequence (520 residues)

MSQDNDTLMR DILGHELAAM RLQKLEQQRR LFEKKQRQKR QELLMVQANP DASPWLWRSC LREERLLGDR GLGNPFLRKK VSEAHLPSGI HSALGTVSCG GDGRGERGLP TPRTEAVFRN LGLQSPFLSW LPDNSDAELE EVSVENGSVS PPPFKQSPRI RRKGWQAHQR PGTRAEGESD SQDMGDAHKS PNMGPNPGMD GDCVYENLAF QKEEDLEKKR EASESTGTNS SAAHNEELSK ALKGEGGTDS DHMRHEASLA IRSPCPGLEE DMEAYVLRPA LPGTMMQCYL TRDKHGVDKG LFPLYYLYLE TSDSLQRFLL AGRKRRRSKT SNYLISLDPT HLSRDGDNFV GKVRSNVFST KFTIFDNGVN PDREHLTRNT ARIRQELGAV CYEPNVLGYL GPRKMTVILP GTNSQNQRIN VQPLNEQESL LSRYQRGDKQ GLLLLHNKTP SWDKENGVYT LNFHGRVTRA SVKNFQIVDP KHQEHLVLQF GRVGPDTFTM DFCFPFSPLQ AFSICLSSFN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards