Chloride intracellular channel protein 1 (CLIC1)

About Chloride intracellular channel protein 1

Chloride intracellular channel protein 1 (CLIC1) is a protein from Homo sapiens identified by UniProt accession O00299, 241 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.

Target properties

Protein name	Chloride intracellular channel protein 1
UniProt accession	O00299
Gene	CLIC1
Organism	Homo sapiens
Length	241 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (236)

Diseases linked to this target (Open Targets).

body height · score 0.24
systolic blood pressure · score 0.24
blood protein measurement · score 0.20
neoplasm · score 0.11
glioblastoma multiforme · score 0.11
esophageal squamous cell carcinoma · score 0.09
hepatocellular carcinoma · score 0.09
Von Willebrand disease · score 0.08
Rare hemorrhagic disorder due to a constitutional platelet anomaly · score 0.08
oral squamous cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00299-F1	alphafold	PREDICTED	94.16	—

Amino-acid sequence (241 residues)

MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards