About Eukaryotic translation initiation factor 3 subunit F
Eukaryotic translation initiation factor 3 subunit F (EIF3F) is a protein
from Homo sapiens identified by UniProt accession
O00303, 357 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 3 subunit F |
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| UniProt accession | O00303 |
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| Gene | EIF3F |
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| Organism | Homo sapiens |
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| Length | 357 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.50
- genetic disorder · score 0.41
- Intellectual disability · score 0.37
- neurodegenerative disease · score 0.37
- syndromic intellectual disability · score 0.37
- Neurodevelopmental disorder · score 0.34
- neurodevelopmental disorder with dysmorphic facies and distal limb anomalies · score 0.34
- mean corpuscular volume · score 0.27
- mean corpuscular hemoglobin · score 0.26
- mean corpuscular hemoglobin concentration · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00303-F1 | alphafold | PREDICTED | 73.88 | — |
Amino-acid sequence (357 residues)
MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL LGTVDKHSVE VTNCFSVPHN ESEDEVAVDM EFAKNMYELH KKVSPNELIL GWYATGHDIT EHSVLIHEYY SREAPNPIHL TVDTSLQNGR MSIKAYVSTL MGVPGRTMGV MFTPLTVKYA YYDTERIGVD LIMKTCFSPN RVIGLSSDLQ QVGGASARIQ DALSTVLQYA EDVLSGKVSA DNTVGRFLMS LVNQVPKIVP DDFETMLNSN INDLLMVTYL ANLTQSQIAL NEKLVNL
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