About Voltage-dependent L-type calcium channel subunit beta-4
Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) is a protein
from Homo sapiens identified by UniProt accession
O00305, 520 residues long.
MolForge cross-references it against 0 known binders and
393 disease associations.
Target properties
| Protein name | Voltage-dependent L-type calcium channel subunit beta-4 |
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| UniProt accession | O00305 |
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| Gene | CACNB4 |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (393)
Diseases linked to this target (Open Targets).
- juvenile myoclonic epilepsy · score 0.63
- episodic ataxia type 5 · score 0.63
- cardiovascular disease · score 0.46
- neurodegenerative disease · score 0.40
- generalized anxiety disorder · score 0.39
- Polyuria · score 0.37
- Urinary incontinence · score 0.37
- gastrointestinal disease · score 0.37
- self reported educational attainment · score 0.32
- anxiety · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00305-F1 | alphafold | PREDICTED | 71.84 | — |
Amino-acid sequence (520 residues)
MSSSSYAKNG TADGPHSPTS QVARGTTTRR SRLKRSDGST TSTSFILRQG SADSYTSRPS DSDVSLEEDR EAIRQEREQQ AAIQLERAKS KPVAFAVKTN VSYCGALDED VPVPSTAISF DAKDFLHIKE KYNNDWWIGR LVKEGCEIGF IPSPLRLENI RIQQEQKRGR FHGGKSSGNS SSSLGEMVSG TFRATPTSTA KQKQKVTEHI PPYDVVPSMR PVVLVGPSLK GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKRAII ERSNTRSSLA EVQSEIERIF ELARSLQLVV LDADTINHPA QLIKTSLAPI IVHVKVSSPK VLQRLIKSRG KSQSKHLNVQ LVAADKLAQC PPEMFDVILD ENQLEDACEH LGEYLEAYWR ATHTTSSTPM TPLLGRNLGS TALSPYPTAI SGLQSQRMRH SNHSTENSPI ERRSLMTSDE NYHNERARKS RNRLSSSSQH SRDHYPLVEE DYPDSYQDTY KPHRNRGSPG GYSHDSRHRL
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