About Cell division cycle 7-related protein kinase
Cell division cycle 7-related protein kinase (CDC7) is a protein
from Homo sapiens identified by UniProt accession
O00311, 574 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Cell division cycle 7-related protein kinase |
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| UniProt accession | O00311 |
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| Gene | CDC7 |
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| Organism | Homo sapiens |
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| Length | 574 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- eosinophil count · score 0.30
- eosinophil percentage of leukocytes · score 0.30
- FEV/FVC ratio · score 0.28
- optic disc area measurement · score 0.26
- cup-to-disc ratio measurement · score 0.26
- optic disc size measurement · score 0.26
- vital capacity · score 0.26
- endometrial cancer · score 0.26
- platelet crit · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00311-F1 | alphafold | PREDICTED | 71.96 | — |
Amino-acid sequence (574 residues)
MEASLGIQMD EPMAFSPQRD RFQAEGSLKK NEQNFKLAGV KKDIEKLYEA VPQLSNVFKI EDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR IAAELQCLTV AGGQDNVMGV KYCFRKNDHV VIAMPYLEHE SFLDILNSLS FQEVREYMLN LFKALKRIHQ FGIVHRDVKP SNFLYNRRLK KYALVDFGLA QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG PVPKELDQQS TTKASVKRPY TNAQIQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH ESPAVKLMKQ SKTVDVLSRK LATKKKAIST KVMNSAVMRK TASSCPASLT CDCYATDKVC SICLSRRQQV APRAGTPGFR APEVLTKCPN QTTAIDMWSA GVIFLSLLSG RYPFYKASDD LTALAQIMTI RGSRETIQAA KTFGKSILCS KEVPAQDLRK LCERLRGMDS STPKLTSDIQ GHASHQPAIS EKTDHKASCL VQTPPGQYSG NSFKKGDSNS CEHCFDEYNT NLEGWNEVPD EAYDLLDKLL DLNPASRITA EEALLHPFFK DMSL
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