ETS translocation variant 2 (ETV2)

About ETS translocation variant 2

ETS translocation variant 2 (ETV2) is a protein from Homo sapiens identified by UniProt accession O00321, 342 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	ETS translocation variant 2
UniProt accession	O00321
Gene	ETV2
Organism	Homo sapiens
Length	342 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

Abnormal vertebral morphology · score 0.32
polydactyly · score 0.32
hypoplastic left heart syndrome · score 0.32
Abnormal heart morphology · score 0.32
congenital heart disease · score 0.32
myocardial infarction · score 0.09
neoplasm · score 0.08
glioblastoma multiforme · score 0.08
cancer · score 0.04
congenitally corrected transposition of the great arteries · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00321-F1	alphafold	PREDICTED	55.62	—

Amino-acid sequence (342 residues)

MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW KGTSSSLASF PQLDWGSALL HPEVPWGAEP DSQALPWSGD WTDMACTAWD SWSGASQTLG PAPLGPGPIP AAGSEGAAGQ NCVPVAGEAT SWSRAQAAGS NTSWDCSVGP DGDTYWGSGL GGEPRTDCTI SWGGPAGPDC TTSWNPGLHA GGTTSLKRYQ SSALTVCSEP SPQSDRASLA RCPKTNHRGP IQLWQFLLEL LHDGARSSCI RWTGNSREFQ LCDPKEVARL WGERKRKPGM NYEKLSRGLR YYYRRDIVRK SGGRKYTYRF GGRVPSLAYP DCAGGGRGAE TQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards