About Uroplakin-1a
Uroplakin-1a (UPK1A) is a protein
from Homo sapiens identified by UniProt accession
O00322, 258 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Uroplakin-1a |
|---|
| UniProt accession | O00322 |
|---|
| Gene | UPK1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 258 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (63)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.24
- body height · score 0.23
- self reported educational attainment · score 0.20
- cortical surface area measurement · score 0.13
- white matter microstructure measurement · score 0.11
- hepatocellular carcinoma · score 0.10
- esophageal squamous cell carcinoma · score 0.09
- age at first sexual intercourse measurement · score 0.08
- cortical thickness · score 0.08
- brain measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00322-F1 | alphafold | PREDICTED | 86.36 | — |
Amino-acid sequence (258 residues)
MASAAAAEAE KGSPVVVGLL VVGNIIILLS GLSLFAETIW VTADQYRVYP LMGVSGKDDV FAGAWIAIFC GFSFFMVASF GVGAALCRRR SMVLTYLVLM LIVYIFECAS CITSYTHRDY MVSNPSLITK QMLTFYSADT DQGQELTRLW DRVMIEQECC GTSGPMDWVN FTSAFRAATP EVVFPWPPLC CRRTGNFIPL NEEGCRLGHM DYLFTKGCFE HIGHAIDSYT WGISWFGFAI LMWTLPVMLI AMYFYTML
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