About Basic helix-loop-helix ARNT-like protein 1
Basic helix-loop-helix ARNT-like protein 1 (BMAL1) is a protein
from Homo sapiens identified by UniProt accession
O00327, 626 residues long.
MolForge cross-references it against 0 known binders and
556 disease associations.
Target properties
| Protein name | Basic helix-loop-helix ARNT-like protein 1 |
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| UniProt accession | O00327 |
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| Gene | BMAL1 |
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| Organism | Homo sapiens |
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| Length | 626 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (556)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.51
- body mass index · score 0.50
- sex hormone-binding globulin measurement · score 0.50
- C-reactive protein measurement · score 0.49
- bilirubin measurement · score 0.46
- hemoglobin measurement · score 0.46
- neuroticism measurement · score 0.46
- erythrocyte count · score 0.46
- worry measurement · score 0.45
- body fat percentage · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00327-F1 | alphafold | PREDICTED | 65.53 | — |
Amino-acid sequence (626 residues)
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE DNEPDNEGCN LSCLVAIGRL HSHVVPQPVN GEIRVKSMEY VSRHAIDGKF VFVDQRATAI LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT TNCYKFKIKD GSFITLRSRW FSFMNPWTKE VEYIVSTNTV VLANVLEGGD PTFPQLTASP HSMDSMLPSG EGGPKRTHPT VPGIPGGTRA GAGKIGRMIA EEIMEIHRIR GSSPSSCGSS PLNITSTPPP DASSPGGKKI LNGGTPDIPS SGLLSGQAQE NPGYPYSDSS SILGENPHIG IDMIDNDQGS SSPSNDEAAM AVIMSLLEAD AGLGGPVDFS DLPWPL
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