About Pyruvate dehydrogenase protein X component, mitochondrial
Pyruvate dehydrogenase protein X component, mitochondrial (PDHX) is a protein
from Homo sapiens identified by UniProt accession
O00330, 501 residues long.
MolForge cross-references it against 0 known binders and
182 disease associations.
Target properties
| Protein name | Pyruvate dehydrogenase protein X component, mitochondrial |
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| UniProt accession | O00330 |
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| Gene | PDHX |
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| Organism | Homo sapiens |
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| Length | 501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (182)
Diseases linked to this target (Open Targets).
- pyruvate dehydrogenase E3-binding protein deficiency · score 0.79
- Leigh syndrome · score 0.37
- genetic disorder · score 0.34
- FEV/FVC ratio · score 0.30
- glucose measurement · score 0.28
- pyruvate dehydrogenase E1-alpha deficiency · score 0.26
- protein measurement · score 0.26
- type 2 diabetes mellitus · score 0.24
- HbA1c measurement · score 0.23
- mean corpuscular volume · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00330-F1 | alphafold | PREDICTED | 77.29 | — |
Amino-acid sequence (501 residues)
MAASWRLGCD PRLLRYLVGF PGRRSVGLVK GALGWSVSRG ANWRWFHSTQ WLRGDPIKIL MPSLSPTMEE GNIVKWLKKE GEAVSAGDAL CEIETDKAVV TLDASDDGIL AKIVVEEGSK NIRLGSLIGL IVEEGEDWKH VEIPKDVGPP PPVSKPSEPR PSPEPQISIP VKKEHIPGTL RFRLSPAARN ILEKHSLDAS QGTATGPRGI FTKEDALKLV QLKQTGKITE SRPTPAPTAT PTAPSPLQAT AGPSYPRPVI PPVSTPGQPN AVGTFTEIPA SNIRRVIAKR LTESKSTVPH AYATADCDLG AVLKVRQDLV KDDIKVSVND FIIKAAAVTL KQMPDVNVSW DGEGPKQLPF IDISVAVATD KGLLTPIIKD AAAKGIQEIA DSVKALSKKA RDGKLLPEEY QGGSFSISNL GMFGIDEFTA VINPPQACIL AVGRFRPVLK LTEDEEGNAK LQQRQLITVT MSSDSRVVDD ELATRFLKSF KANLENPIRL A
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