About Excitatory amino acid transporter 5
Excitatory amino acid transporter 5 (SLC1A7) is a protein
from Homo sapiens identified by UniProt accession
O00341, 560 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Excitatory amino acid transporter 5 |
|---|
| UniProt accession | O00341 |
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| Gene | SLC1A7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 560 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.44
- body height · score 0.40
- tuberculin skin test reactivity measurement · score 0.30
- sitting height measurement · score 0.29
- creatinine measurement · score 0.29
- forced expiratory volume · score 0.20
- vital capacity · score 0.20
- Barrett's esophagus · score 0.04
- thyroid disease · score 0.04
- Crohn's disease · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00341-F1 | alphafold | PREDICTED | 77.37 | — |
Amino-acid sequence (560 residues)
MVPHAILARG RDVCRRNGLL ILSVLSVIVG CLLGFFLRTR RLSPQEISYF QFPGELLMRM LKMMILPLVV SSLMSGLASL DAKTSSRLGV LTVAYYLWTT FMAVIVGIFM VSIIHPGSAA QKETTEQSGK PIMSSADALL DLIRNMFPAN LVEATFKQYR TKTTPVVKSP KVAPEEAPPR RILIYGVQEE NGSHVQNFAL DLTPPPEVVY KSEPGTSDGM NVLGIVFFSA TMGIMLGRMG DSGAPLVSFC QCLNESVMKI VAVAVWYFPF GIVFLIAGKI LEMDDPRAVG KKLGFYSVTV VCGLVLHGLF ILPLLYFFIT KKNPIVFIRG ILQALLIALA TSSSSATLPI TFKCLLENNH IDRRIARFVL PVGATINMDG TALYEAVAAI FIAQVNNYEL DFGQIITISI TATAASIGAA GIPQAGLVTM VIVLTSVGLP TDDITLIIAV DWALDRFRTM INVLGDALAA GIMAHICRKD FARDTGTEKL LPCETKPVSL QEIVAAQQNG CVKSVAEASE LTLGPTCPHH VPVQVEQDEE LPAASLNHCT IQISELETNV
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