Forkhead box protein E1 (FOXE1)

About Forkhead box protein E1

Forkhead box protein E1 (FOXE1) is a protein from Homo sapiens identified by UniProt accession O00358, 373 residues long. MolForge cross-references it against 0 known binders and 203 disease associations.

Target properties

Protein name	Forkhead box protein E1
UniProt accession	O00358
Gene	FOXE1
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (203)

Diseases linked to this target (Open Targets).

Bamforth-Lazarus syndrome · score 0.78
thyroid cancer, nonmedullary, 4 · score 0.48
congenital hypothyroidism · score 0.41
hypothyroidism · score 0.40
thyroid carcinoma · score 0.40
follicular thyroid carcinoma · score 0.39
Cleft palate · score 0.38
cleft palate · score 0.38
familial papillary or follicular thyroid carcinoma · score 0.37
choanal atresia · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00358-F1	alphafold	PREDICTED	60.12	—

Amino-acid sequence (373 residues)

MTAESGPPPP QPEVLATVKE ERGETAAGAG VPGEATGRGA GGRRRKRPLQ RGKPPYSYIA LIAMAIAHAP ERRLTLGGIY KFITERFPFY RDNPKKWQNS IRHNLTLNDC FLKIPREAGR PGKGNYWALD PNAEDMFESG SFLRRRKRFK RSDLSTYPAY MHDAAAAAAA AAAAAAAAAI FPGAVPAARP PYPGAVYAGY APPSLAAPPP VYYPAASPGP CRVFGLVPER PLSPELGPAP SGPGGSCAFA SAGAPATTTG YQPAGCTGAR PANPSAYAAA YAGPDGAYPQ GAGSAIFAAA GRLAGPASPP AGGSSGGVET TVDFYGRTSP GQFGALGACY NPGGQLGGAS AGAYHARHAA AYPGGIDRFV SAM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards