About Dynactin subunit 6
Dynactin subunit 6 (DCTN6) is a protein
from Homo sapiens identified by UniProt accession
O00399, 190 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Dynactin subunit 6 |
|---|
| UniProt accession | O00399 |
|---|
| Gene | DCTN6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 190 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (23)
Diseases linked to this target (Open Targets).
- grip strength measurement · score 0.16
- BMI-adjusted waist circumference · score 0.10
- balding measurement · score 0.10
- hair shape measurement · score 0.07
- mental or behavioural disorder · score 0.06
- spontaneous preterm birth · score 0.06
- parental genotype effect measurement · score 0.06
- mammographic density percentage · score 0.05
- male infertility · score 0.03
- hair colour measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00399-F1 | alphafold | PREDICTED | 71.05 | — |
Amino-acid sequence (190 residues)
MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIVI GEGNLIEEQA LIINAYPDNI TPDTEDPEPK PMIIGTNNVF EVGCYSQAMK MGDNNVIESK AYVGRNVILT SGCIIGACCN LNTFEVIPEN TVIYGADCLR RVQTERPQPQ TLQLDFLMKI LPNYHHLKKT MKGSSTPVKN
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