About Acetyl-coenzyme A transporter 1
Acetyl-coenzyme A transporter 1 (SLC33A1) is a protein
from Homo sapiens identified by UniProt accession
O00400, 549 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Acetyl-coenzyme A transporter 1 |
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| UniProt accession | O00400 |
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| Gene | SLC33A1 |
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| Organism | Homo sapiens |
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| Length | 549 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- Huppke-Brendel syndrome · score 0.71
- Autosomal dominant spastic paraplegia type 42 · score 0.64
- hereditary spastic paraplegia 42 · score 0.54
- neurodegenerative disease · score 0.46
- Spastic paraplegia · score 0.42
- hereditary spastic paraplegia · score 0.41
- hemochromatosis · score 0.37
- cataract · score 0.37
- alkaline phosphatase measurement · score 0.27
- serum alanine aminotransferase measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00400-F1 | alphafold | PREDICTED | 82.36 | — |
Amino-acid sequence (549 residues)
MSPTISHKDS SRQRRPGNFS HSLDMKSGPL PPGGWDDSHL DSAGREGDRE ALLGDTGTGD FLKAPQSFRA ELSSILLLLF LYVLQGIPLG LAGSIPLILQ SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYVKNFGRR KSWLVPTQYI LGLFMIYLST QVDRLLGNTD DRTPDVIALT VAFFLFEFLA ATQDIAVDGW ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENEVSVVKEE TQGITDTYKL LFAIIKMPAV LTFCLLILTA KIGFSAADAV TGLKLVEEGV PKEHLALLAV PMVPLQIILP LIISKYTAGP QPLNTFYKAM PYRLLLGLEY ALLVWWTPKV EHQGGFPIYY YIVVLLSYAL HQVTVYSMYV SIMAFNAKVS DPLIGGTYMT LLNTVSNLGG NWPSTVALWL VDPLTVKECV GASNQNCRTP DAVELCKKLG GSCVTALDGY YVESIICVFI GFGWWFFLGP KFKKLQDEGS SSWKCKRNN
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