Actin nucleation-promoting factor WASL (WASL)

About Actin nucleation-promoting factor WASL

Actin nucleation-promoting factor WASL (WASL) is a protein from Homo sapiens identified by UniProt accession O00401, 505 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Actin nucleation-promoting factor WASL
UniProt accession	O00401
Gene	WASL
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

platelet count · score 0.35
neurodegenerative disease · score 0.33
mean platelet volume · score 0.31
mean corpuscular hemoglobin concentration · score 0.31
reticulocyte count · score 0.29
mean corpuscular volume · score 0.29
platelet crit · score 0.27
reticulocyte measurement · score 0.27
HbA1c measurement · score 0.24
calcium measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00401-F1	alphafold	PREDICTED	68.74	—

Amino-acid sequence (505 residues)

MSSVQQQPPP PRRVTNVGSL LLTPQENESL FTFLGKKCVT MSSAVVQLYA ADRNCMWSKK CSGVACLVKD NPQRSYFLRI FDIKDGKLLW EQELYNNFVY NSPRGYFHTF AGDTCQVALN FANEEEAKKF RKAVTDLLGR RQRKSEKRRD PPNGPNLPMA TVDIKNPEIT TNRFYGPQVN NISHTKEKKK GKAKKKRLTK ADIGTPSNFQ HIGHVGWDPN TGFDLNNLDP ELKNLFDMCG ISEAQLKDRE TSKVIYDFIE KTGGVEAVKN ELRRQAPPPP PPSRGGPPPP PPPPHNSGPP PPPARGRGAP PPPPSRAPTA APPPPPPSRP SVAVPPPPPN RMYPPPPPAL PSSAPSGPPP PPPSVLGVGP VAPPPPPPPP PPPGPPPPPG LPSDGDHQVP TTAGNKAALL DQIREGAQLK KVEQNSRPVS CSGRDALLDQ IRQGIQLKSV ADGQESTPPT PAPTSGIVGA LMEVMQKRSK AIHSSDEDED EDDEEDFEDD DEWED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards