Forkhead box protein N3 (FOXN3)

About Forkhead box protein N3

Forkhead box protein N3 (FOXN3) is a protein from Homo sapiens identified by UniProt accession O00409, 490 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	Forkhead box protein N3
UniProt accession	O00409
Gene	FOXN3
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
glucose measurement · score 0.47
sex hormone-binding globulin measurement · score 0.47
high density lipoprotein cholesterol measurement · score 0.45
electrocardiography · score 0.44
self reported educational attainment · score 0.42
testosterone measurement · score 0.42
heel bone mineral density · score 0.38
intelligence · score 0.38
HbA1c measurement · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00409-F1	alphafold	PREDICTED	57.62	—

Amino-acid sequence (490 residues)

MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL EEGAMEDEEL TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS QSIGKGSLWC IDPEYRQNLI QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF KRNGALLQDP DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP TSDSISSSSS SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH SQKEPKDSLG DSGYASQHKK RQHFAKARKV PSDTLPLKKR RTEKPPESDD EEMKEAAGSL LHLAGIRSCL NNITNRTAKG QKEQKETTKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards