About Eukaryotic elongation factor 2 kinase
Eukaryotic elongation factor 2 kinase (EEF2K) is a protein
from Homo sapiens identified by UniProt accession
O00418, 725 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Eukaryotic elongation factor 2 kinase |
|---|
| UniProt accession | O00418 |
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| Gene | EEF2K |
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| Organism | Homo sapiens |
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| Length | 725 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (154)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.41
- breast adenocarcinoma · score 0.28
- thyroid gland adenocarcinoma · score 0.28
- neurodegenerative disease · score 0.27
- lung adenocarcinoma · score 0.27
- endometrial cancer · score 0.18
- neoplasm · score 0.11
- melanoma · score 0.10
- triple-negative breast cancer · score 0.10
- Rheumatoid arthritis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00418-F1 | alphafold | PREDICTED | 71.82 | — |
Amino-acid sequence (725 residues)
MADEDLIFRL EGVDGGQSPR AGHDGDSDGD SDDEEGYFIC PITDDPSSNQ NVNSKVNKYY SNLTKSERYS SSGSPANSFH FKEAWKHAIQ KAKHMPDPWA EFHLEDIATE RATRHRYNAV TGEWLDDEVL IKMASQPFGR GAMRECFRTK KLSNFLHAQQ WKGASNYVAK RYIEPVDRDV YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCIIELKDR PGKPLFHLEH YIEGKYIKYN SNSGFVRDDN IRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE TGTDFGDGNL GVRGMALFFY SHACNRICES MGLAPFDLSP RERDAVNQNT KLLQSAKTIL RGTEEKCGSP QVRTLSGSRP PLLRPLSENS GDENMSDVTF DSLPSSPSSA TPHSQKLDHL HWPVFSDLDN MASRDHDHLD NHRESENSGD SGYPSEKRGE LDDPEPREHG HSYSNRKYES DEDSLGSSGR VCVEKWNLLN SSRLHLPRAS AVALEVQRLN ALDLEKKIGK SILGKVHLAM VRYHEGGRFC EKGEEWDQES AVFHLEHAAN LGELEAIVGL GLMYSQLPHH ILADVSLKET EENKTKGFDY LLKAAEAGDR QSMILVARAF DSGQNLSPDR CQDWLEALHW YNTALEMTDC DEGGEYDGMQ DEPRYMMLAR EAEMLFTGGY GLEKDPQRSG DLYTQAAEAA MEAMKGRLAN QYYQKAEEAW AQMEE
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