C-C chemokine receptor-like 2 (CCRL2)

About C-C chemokine receptor-like 2

C-C chemokine receptor-like 2 (CCRL2) is a protein from Homo sapiens identified by UniProt accession O00421, 344 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.

Target properties

Protein name	C-C chemokine receptor-like 2
UniProt accession	O00421
Gene	CCRL2
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (145)

Diseases linked to this target (Open Targets).

CCL4 measurement · score 0.26
monocyte count · score 0.23
ulcerative colitis · score 0.23
monocyte percentage of leukocytes · score 0.22
viral load · score 0.22
macrophage inflammatory protein 1b measurement · score 0.21
HIV-1 infection · score 0.21
psoriasis · score 0.21
Crohn's disease · score 0.21
sclerosing cholangitis · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00421-F1	alphafold	PREDICTED	77.80	—

Amino-acid sequence (344 residues)

MANYTLAPED EYDVLIEGEL ESDEAEQCDK YDAQALSAQL VPSLCSAVFV IGVLDNLLVV LILVKYKGLK RVENIYLLNL AVSNLCFLLT LPFWAHAGGD PMCKILIGLY FVGLYSETFF NCLLTVQRYL VFLHKGNFFS ARRRVPCGII TSVLAWVTAI LATLPEFVVY KPQMEDQKYK CAFSRTPFLP ADETFWKHFL TLKMNISVLV LPLFIFTFLY VQMRKTLRFR EQRYSLFKLV FAIMVVFLLM WAPYNIAFFL STFKEHFSLS DCKSSYNLDK SVHITKLIAT THCCINPLLY AFLDGTFSKY LCRCFHLRSN TPLQPRGQSA QGTSREEPDH STEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards