About Histone deacetylase complex subunit SAP18
Histone deacetylase complex subunit SAP18 (SAP18) is a protein
from Homo sapiens identified by UniProt accession
O00422, 153 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Histone deacetylase complex subunit SAP18 |
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| UniProt accession | O00422 |
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| Gene | SAP18 |
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| Organism | Homo sapiens |
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| Length | 153 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- neoplasm · score 0.08
- attention deficit-hyperactivity disorder 8 · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- schizophrenia 15 · score 0.07
- Phelan-McDermid syndrome · score 0.05
- X-linked non-syndromic intellectual disability · score 0.04
- nonpapillary renal cell carcinoma · score 0.02
- systemic juvenile idiopathic arthritis · score 0.02
- Abnormal sperm morphology · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00422-F1 | alphafold | PREDICTED | 87.09 | — |
Amino-acid sequence (153 residues)
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY
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