About Insulin-like growth factor 2 mRNA-binding protein 3
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is a protein
from Homo sapiens identified by UniProt accession
O00425, 579 residues long.
MolForge cross-references it against 0 known binders and
281 disease associations.
Target properties
| Protein name | Insulin-like growth factor 2 mRNA-binding protein 3 |
|---|
| UniProt accession | O00425 |
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| Gene | IGF2BP3 |
|---|
| Organism | Homo sapiens |
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| Length | 579 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (281)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- body height · score 0.48
- refractive error measurement · score 0.47
- lean body mass · score 0.47
- birth weight · score 0.46
- leukocyte count · score 0.44
- vital capacity · score 0.44
- BMI-adjusted hip circumference · score 0.42
- appendicular lean mass · score 0.40
- neutrophil count · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00425-F1 | alphafold | PREDICTED | 77.49 | — |
Amino-acid sequence (579 residues)
MNKLYIGNLS ENAAPSDLES IFKDAKIPVS GPFLVKTGYA FVDCPDESWA LKAIEALSGK IELHGKPIEV EHSVPKRQRI RKLQIRNIPP HLQWEVLDSL LVQYGVVESC EQVNTDSETA VVNVTYSSKD QARQALDKLN GFQLENFTLK VAYIPDEMAA QQNPLQQPRG RRGLGQRGSS RQGSPGSVSK QKPCDLPLRL LVPTQFVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA EKSITILSTP EGTSAACKSI LEIMHKEAQD IKFTEEIPLK ILAHNNFVGR LIGKEGRNLK KIEQDTDTKI TISPLQELTL YNPERTITVK GNVETCAKAE EEIMKKIRES YENDIASMNL QAHLIPGLNL NALGLFPPTS GMPPPTSGPP SAMTPPYPQF EQSETETVHL FIPALSVGAI IGKQGQHIKQ LSRFAGASIK IAPAEAPDAK VRMVIITGPP EAQFKAQGRI YGKIKEENFV SPKEEVKLEA HIRVPSFAAG RVIGKGGKTV NELQNLSSAE VVVPRDQTPD ENDQVVVKIT GHFYACQVAQ RKIQEILTQV KQHQQQKALQ SGPPQSRRK
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