About Dynamin-1-like protein
Dynamin-1-like protein (DNM1L) is a protein
from Homo sapiens identified by UniProt accession
O00429, 736 residues long.
MolForge cross-references it against 0 known binders and
390 disease associations.
Target properties
| Protein name | Dynamin-1-like protein |
|---|
| UniProt accession | O00429 |
|---|
| Gene | DNM1L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 736 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (390)
Diseases linked to this target (Open Targets).
- Lethal encephalopathy due to mitochondrial and peroxisomal fission defect · score 0.79
- encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 · score 0.79
- Autosomal dominant optic atrophy, classic type · score 0.71
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.45
- mean platelet volume · score 0.39
- mitochondrial disease · score 0.38
- encephalopathy due to mitochondrial and peroxisomal fission defect · score 0.37
- autosomal dominant optic atrophy, classic form · score 0.37
- platelet count · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00429-F1 | alphafold | PREDICTED | 76.46 | — |
Amino-acid sequence (736 residues)
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL QGASQIIAEI RETHLW
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