RNA 3'-terminal phosphate cyclase (RTCA)

About RNA 3'-terminal phosphate cyclase

RNA 3'-terminal phosphate cyclase (RTCA) is a protein from Homo sapiens identified by UniProt accession O00442, 366 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	RNA 3'-terminal phosphate cyclase
UniProt accession	O00442
Gene	RTCA
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.12
myeloid white cell count · score 0.12
leukocyte count · score 0.12
lymphocyte count · score 0.07
neoplasm · score 0.01
ovarian carcinoma · score 0.01
Plasmodium falciparum malaria · score 0.01
oral squamous cell carcinoma · score 0.01
chronic kidney disease · score 0.01
non-small cell lung carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00442-F1	alphafold	PREDICTED	95.81	—

Amino-acid sequence (366 residues)

MAGPRVEVDG SIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP QHLSGLEMIR DLCDGQLEGA EIGSTEITFT PEKIKGGIHT ADTKTAGSVC LLMQVSMPCV LFAASPSELH LKGGTNAEMA PQIDYTVMVF KPIVEKFGFI FNCDIKTRGY YPKGGGEVIV RMSPVKQLNP INLTERGCVT KIYGRAFVAG VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF GNGNGIIIIA ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGT VDEYLQDQLI VFMALANGVS RIKTGPVTLH TQTAIHFAEQ IAKAKFIVKK SEDEEDAAKD TYIIECQGIG MTNPNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards