GDNF family receptor alpha-2 (GFRA2)

About GDNF family receptor alpha-2

GDNF family receptor alpha-2 (GFRA2) is a protein from Homo sapiens identified by UniProt accession O00451, 464 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	GDNF family receptor alpha-2
UniProt accession	O00451
Gene	GFRA2
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.42
trait in response to pazopanib · score 0.33
GDNF family receptor alpha-2 measurement · score 0.33
breast adenocarcinoma · score 0.29
DNA methylation · score 0.27
frontotemporal dementia · score 0.26
self reported educational attainment · score 0.26
neurodegenerative disease · score 0.25
fat body mass · score 0.20
serum albumin measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00451-F1	alphafold	PREDICTED	74.99	—

Amino-acid sequence (464 residues)

MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards