Interferon-related developmental regulator 1 (IFRD1)

About Interferon-related developmental regulator 1

Interferon-related developmental regulator 1 (IFRD1) is a protein from Homo sapiens identified by UniProt accession O00458, 451 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Interferon-related developmental regulator 1
UniProt accession	O00458
Gene	IFRD1
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

spinocerebellar ataxia type 18 · score 0.37
monocyte count · score 0.34
gut microbiome measurement · score 0.27
monocyte percentage of leukocytes · score 0.23
electrocardiography · score 0.14
mathematical ability · score 0.14
Abnormality of refraction · score 0.12
Charcot-Marie-Tooth disease · score 0.11
pleural disorder · score 0.08
hepatocellular carcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00458-F1	alphafold	PREDICTED	83.60	—

Amino-acid sequence (451 residues)

MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET MSHCSGYSDP SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ AALEGIKNAL ASKMLYEFIL ERRMTLTDSI ERCLKKGKSD EQRAAAALAS VLCIQLGPGI ESEEILKTLG PILKKIICDG SASMQARQTC ATCFGVCCFI ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL HISSLLAWTL LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD FPTETIKFGP ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE LGPPVMLDAA TLKTMKISRF ERHLYNSAAF KARTKARSKC RDKRADVGEF F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards