About Phosphatidylinositol 3-kinase regulatory subunit beta
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) is a protein
from Homo sapiens identified by UniProt accession
O00459, 728 residues long.
MolForge cross-references it against 0 known binders and
237 disease associations.
Target properties
| Protein name | Phosphatidylinositol 3-kinase regulatory subunit beta |
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| UniProt accession | O00459 |
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| Gene | PIK3R2 |
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| Organism | Homo sapiens |
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| Length | 728 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (237)
Diseases linked to this target (Open Targets).
- Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus · score 0.82
- cancer · score 0.58
- overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes · score 0.46
- Seizure · score 0.44
- genetic disorder · score 0.41
- non-small cell lung carcinoma · score 0.40
- neurodegenerative disease · score 0.37
- megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome · score 0.37
- multiple sclerosis · score 0.36
- breast cancer · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00459-F1 | alphafold | PREDICTED | 81.65 | — |
Amino-acid sequence (728 residues)
MAGPEGFQYR ALYPFRRERP EDLELLPGDV LVVSRAALQA LGVAEGGERC PQSVGWMPGL NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP RDGAPEPGLT LPDLPEQFSP PDVAPPLLVK LVEAIERTGL DSESHYRPEL PAPRTDWSLS DVDQWDTAAL ADGIKSFLLA LPAPLVTPEA SAEARRALRE AAGPVGPALE PPTLPLHRAL TLRFLLQHLG RVASRAPALG PAVRALGATF GPLLLRAPPP PSSPPPGGAP DGSEPSPDFP ALLVEKLLQE HLEEQEVAPP ALPPKPPKAK PASTVLANGG SPPSLQDAEW YWGDISREEV NEKLRDTPDG TFLVRDASSK IQGEYTLTLR KGGNNKLIKV FHRDGHYGFS EPLTFCSVVD LINHYRHESL AQYNAKLDTR LLYPVSKYQQ DQIVKEDSVE AVGAQLKVYH QQYQDKSREY DQLYEEYTRT SQELQMKRTA IEAFNETIKI FEEQGQTQEK CSKEYLERFR REGNEKEMQR ILLNSERLKS RIAEIHESRT KLEQQLRAQA SDNREIDKRM NSLKPDLMQL RKIRDQYLVW LTQKGARQKK INEWLGIKNE TEDQYALMED EDDLPHHEER TWYVGKINRT QAEEMLSGKR DGTFLIRESS QRGCYACSVV VDGDTKHCVI YRTATGFGFA EPYNLYGSLK ELVLHYQHAS LVQHNDALTV TLAHPVRAPG PGPPPAAR
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