About Golgi integral membrane protein 4
Golgi integral membrane protein 4 (GOLIM4) is a protein
from Homo sapiens identified by UniProt accession
O00461, 696 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Golgi integral membrane protein 4 |
|---|
| UniProt accession | O00461 |
|---|
| Gene | GOLIM4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 696 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.38
- body height · score 0.35
- body mass index · score 0.27
- type 2 diabetes mellitus · score 0.26
- lean body mass · score 0.09
- proliferative diabetic retinopathy · score 0.09
- neoplasm · score 0.08
- hypertension · score 0.05
- protein measurement · score 0.02
- breast milk measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00461-F1 | alphafold | PREDICTED | 67.59 | — |
Amino-acid sequence (696 residues)
MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY QQHQESLSAQ LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL NKGRQDSNSR YSALNVQHQM LKSQHEELKK QHSDLEEEHR KQGEDFSRTF NDHKQKYLQL QQEKEQELSK LKETVYNLRE ENRQLRKAHQ DIHTQLQDVK QQHKNLLSEH EQLVVTLEDH KSALAAAQTQ VAEYKQLKDT LNRIPSLRKP DPAEQQNVTQ VAHSPQGYNT AREKPTREVQ EVSRNNDVWQ NHEAVPGRAE DTKLYAPTHK EAEFQAPPEP IQQEVERREP EEHQVEEEHR KALEEEEMEQ VGQAEHLEEE HDPSPEEQDR EWKEQHEQRE AANLLEGHAR AEVYPSAKPM IKFQSPYEEQ LEQQRLAVQQ VEEAQQLREH QEALHQQRLQ GHLLRQQEQQ QQQVAREMAL QRQAELEEGR PQHQEQLRQQ AHYDAMDNDI VQGAEDQGIQ GEEGAYERDN QHQDEAEGDP GNRHEPREQG PREADPESEA DRAAVEDINP ADDPNNQGED EFEEAEQVRE ENLPDENEEQ KQSNQKQENT EVEEHLVMAG NPDQQEDNVD EQYQEEAEEE VQEDLTEEKK RELEHNAEET YGENDENTDD KNNDGEEQEV RDDNRPKGRE EHYEEEEEEE EDGAAVAEKS HRRAEM
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