About TNF receptor-associated factor 5
TNF receptor-associated factor 5 (TRAF5) is a protein
from Homo sapiens identified by UniProt accession
O00463, 557 residues long.
MolForge cross-references it against 0 known binders and
169 disease associations.
Target properties
| Protein name | TNF receptor-associated factor 5 |
|---|
| UniProt accession | O00463 |
|---|
| Gene | TRAF5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 557 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (169)
Diseases linked to this target (Open Targets).
- multiple myeloma · score 0.27
- self reported educational attainment · score 0.22
- intelligence · score 0.20
- mean corpuscular hemoglobin concentration · score 0.20
- platelet count · score 0.19
- blood urea nitrogen measurement · score 0.18
- schizophrenia · score 0.15
- mean corpuscular hemoglobin · score 0.13
- mathematical ability · score 0.12
- platelet crit · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00463-F1 | alphafold | PREDICTED | 86.91 | — |
Amino-acid sequence (557 residues)
MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD DTLFLKVAVD LTDLEDL
Explore TNF receptor-associated factor 5 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets